Chapter by F. Brad Johnson “Fundamentals of quadruplexes and their biology”  read in book
Commentary by Prof. Chaires
G-quadruplexes (G4) have evolved from being a biophysical oddity to being structures of functional significance in biology.  For the chemist or physical scientist, appreciation of the possible roles of G4 structures in biology can be difficult because of the scientific cultural divide.  Biologists speak a different language.  This outstanding review by Brad Johnson presents an insightful and crystal-clear overview G4 biology.  It is particularly helpful that he offers explanations of the methods used for studies of G4s in biology, and points out the strengths, weaknesses and potential problems with each approach. As a biophysicist, I have struggled to keep up with, and understand, the rapid advances in G4 biology.  This is the most helpful and insightful review of the subject I have ever seen.